Pickering emulsions stabilized with chitosan/gum Arabic particles: Effect of chitosan degree of deacetylation on the physicochemical properties and cannabidiol (CBD) topical delivery

Pickering emulsions (PEs) have recently gained increasing attention as green carriers of bioactive agents due to their surfactant-free and eco-friendly nature. Herein, the effect degree deacetylation (DDA) chitosan on properties chitosan/gum Arabic (CH/GA) particles PEs was investigated. CH/GA with a DDA 96% (high DDA) 78% (low were prepared. The contact angle water drop for prepared high low 84.2° 77.5°, respectively. dynamic interfacial tension has shown lower values chitosan. PE formulation exhibited higher stability after two months storage than its counterpart mean emulsion droplet size 15.6 ± 4.3 µm 21.1 2.6 chitosan, Both formulations demonstrated shear thinning elastic gel-like properties. amount cannabidiol absorbed by stratum corneum, viable epidermis dermis significantly in both permeated amount, but no significant difference observed between amounts from formulations.